IBD Medication Guide



Brand Name(s)


Drug Class


How taken

Oral and injection under the skin (subcutaneous)

Used for

Active Crohn’s disease

Recommendations for Pregnancy

Contraindicated: teratogenic

Recommendations for Lactation

Contraindicated. Females and males of reproductive potential: Methotrexate may decrease the effectiveness of oral contraceptives. Talk to your doctor.

Medication indication

NOTE: This medication has been typically used for the treatment of Crohn's disease. Talk to your doctor about potential risks and side effects.

Indicated for pediatric use

NOTE: This medication may be recommended for pediatric use. Be sure to talk to your doctor about potential risks and side effects.

Most common side effects

Common side effects include influenza-like symptoms (nausea, vomiting, diarrhea, and low white blood count) hair loss, headache, dizziness, drowsiness, and mouth sores.


Not recommended for individuals with pre-existing liver disease. Known to cause birth defects. It is recommended for patients to stop methotrexate at least three months prior to planned conception. Reduces the absorption of folic acid. Fibrosis and lung inflammation are also rare side effects.

Learn more about immunomodulators

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