IBD Medication Guide



Brand Name(s)


Drug Class

Targeted Synthetic Small Molecules

How taken


Used for

moderate-to-severe ulcerative colitis

Recommendations for Pregnancy

Do not use upadacitinib if you are pregnant or plan to become pregnant. Based on animal studies, upadacitinib may harm your unborn baby. You should use effective birth control (contraception) to avoid becoming pregnant during treatment with upadacitinib and for 4 weeks after your last dose.

Recommendations for Lactation

Upadacitinib may pass into your breast milk. Do not breastfeed during treatment with RINVOQ and for 6 days after your last dose.

Medication indication

moderate-to-severe ulcerative colitis

Indicated for pediatric use

No. Not currently approved for pediatric use.

Most common side effects

Common side effects may include headache, fatigue, acne, nausea, urinary tract infection, and elevated cholesterol


Taking upadacitinib may include risk of serious infections, blood clots, certain types of cancer, and may increase risk of death or major cardiovascular events .

To see the full prescribing information for this medication, click here.

Learn more about targeted synthetic small molecules

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